Vader was a mainstay of wrestling in the 90s – being an international megastar before signing with WWE.
He stood 6ft 4in tall and weighed over 450lbs, being famed for his incredible athletic feats for his size.
Real name Leon White, he was an American football player before turning to professional wrestling in 1985.
Vader and his fans had been rallying to have him inducted into the WWE Hall of Fame in the months leading up to his death.
And the wrestler, from Colorado, had been candid about his long health fight – keeping them updated with numerous surgeries and hospital visits.
Family: His heart had enough and it was his time
Vader is regarded as one of the greatest super heavyweight wrestlers of all time and last appeared in WWE back in 2012.
He was involved in a skit with WWE superstar Heath Slater – returning to the ring and squashing the One Man Band with a brutal Vader Bomb.
In a statement on Twitter his family confirmed he died on Monday night after a battle with pneumonia.
Two pictures of White were shared, featuring a snap of him smiling enjoying a drink and one posing with a championship belt in his golden years.
"Around a month ago my father was diagnosed with a severe case of pneumonia.
"He fought extremely hard and clinically was making progress.
"Unfortunately, on Monday night his heart had enough and it was his time.
reviously, the six-time world champion revealed has revealed his doctors believed his “heart is worn out”.
And Vader had candidly tweeted he accepted his potentially short time left as now “part of reality”.
He was always famed for his agility despite his size, being able to perform his “Vadersault” flip from the ropes.
The Mastadon wrestled in WWE from 1996 to 1998 and previously enjoyed major success in rival company WCW and in Japan.
BIG VAN VADER: His family announced his passing on Twitter
Back in April, Vader tweeted; "Damn I have bad news, I am back in hospital.
“My pain is through the roof and they say I have pneumonia.
“Can’t breath, but I am still fighting. Vader time.”
He also shared a picture of his massive scar from the surgery running down his chest after undergoing open heart surgery.
WWE producer Bruce Prichard tweeted: "So sad to hear of the passing of Leon White, Vader. Leon was so far ahead of his time."
His death is the latest tragedy to rock the wrestling world, which has been blighted by performers having early deaths.
Earlier this year, Big Bully Busick died after losing a cancer fight aged 63.